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Curcumin-a promising candidate for preventing COVID-19

- 8 min read
written by Shield Connect

COVID-19- caused by a newly discovered coronavirus has affected millions of people worldwide.

COVID-19- caused by a newly discovered coronavirus has affected millions of people worldwide. Most people who fall sick with this devastating respiratory disease will experience serious complications, including severe pneumonia, acute respiratory distress syndrome (ARDS), and multiorgan failure due to exaggerated host immune response.

Combating this newly emerging viruses has always been a challenge. The discovery and development of an effective therapeutic agent against COVID-19 is a time-consuming process. Global vaccine rollout has moved at an inspiring speed, the search for new safe, effective, and targeted therapies is still on. During this health emergency, food nutraceuticals could be promising prophylactic therapeutics for COVID-19.

Besides vaccine trials, few therapeutics such as remdesivir and or interferon-beta based on prior knowledge of antiviral activity against SARS-CoV, are in clinical practice for the treatment of COVID-19. The ability of curcumin to modulate a wide range of molecular targets makes it a suitable candidate for the management of coronavirus infection.

Curcumin is extensively available and assist at systemic and pleiotropic effects via several key mechanisms. It is known to impede pro-inflammatory pathways such as PI3k/akt/NF-kB activation. It is also a potent antioxidant and free radical scavenger via a chronological proton loss electron transfer mechanism in ionizing solvents due to its extended conjugating ability across the entire molecule, and its ability to induce NRF-2. It has been implicated in the treatment of diseases ranging from asthma to various cancers and is also a broad spectrum anti-microbial.

Curcumin may have Useful effects against COVID-19 infection via its ability to modify the various molecular targets that contribute to the attachment and internalization of SARS-CoV-2 in many organs, including the liver, cardiovascular system, and kidney. Curcumin could also regulate cellular signaling pathways such as inflammation, apoptosis, and RNA replication. Curcumin may also reduce pulmonary edema and fibrosis-associated pathways in COVID-19 infection.

Mechanism Of Action
Curcumin
The schematic diagram represents the potential mechanisms by which curcumin may be effective against COVID-19 (A) Antiviral activity of curcumin against SARS-CoV-2 mediated by disrupting the viral envelope, S protein and or ACE2, which prevents the entry of the virus into the cells. B. Curcumin induces antiviral responses by positively regulating NRF2 and repressing ACE2 expression by negatively regulating HMGB1. C. Curcumin mediates immunomodulatory responses by inhibiting cytokine response syndrome and oxidative stress and thus mitigating the progression to pneumonia and or ARDS following SARS-CoV-2 infection.

To conclude Curcumin as an antiviral agent can be helpful for both prevention and treatment of new emerging coronavirus. Well documented anti-inflammatory and immunomodulatory effects of curcumin along with the evidence on the anti-fibrotic and Pulmonoprotective effects of this phytochemical on the lung tissue make it a promising candidate for the treatment of COVID-19.Curcumin is also known to have strong inhibitory effects on NF-κB and several pro-inflammatory cytokines, it can be particularly helpful as an adjunct in reversing the fatal cytokine storm that occurs in serious cases of COVID-19.

Reference
1.Thimmulappa RK, Mudnakudu-Nagaraju KK, Shivamallu C, Subramaniam KJT, Radhakrishnan A, Bhojraj S, Kuppusamy G. Antiviral and immunomodulatory activity of curcumin: A case for prophylactic therapy for COVID-19. Heliyon. 2021 Feb;7(2): 06350.
2.Shrinjana Dhar, Pritha Bhattacharjee, Promising role of curcumin against viral diseases emphasizing COVID-19 management: A review on the mechanistic insights with reference to host-pathogen interaction and immunomodulation,
Journal of Functional Foods, Volume 82, 2021.

Dr. PRADYUT WAGHRAY Dr. PRADYUT WAGHRAY MD (CHEST), FCCP(USA), FRCP(London, UK), FCCP (India), FAMS (India) PROF. AND HOD OF PULMONARY MEDICINE, SVS MEDICAL COLLEGE,MAHBUBNAGAR. MANAGING DIRECTOR AND CHIEF PULMONOLOGIST OF KUNAL INSTITUTE OF PULMONOLOGY,HYDERABAD. SR. CONSULTANT PULMONOLOGIST, APOLLO HOSPITALS,HYDERABAD
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